I don’t dislike the idea, but I don’t think it makes sense for U4.
The system makes sense as a way to combat players hoarding tons of large items, because the random-ish slots becoming unusable makes it harder to efficiently store items. A mechanic like this makes a lot of sense when players have a lot of storage space, and that storage space shouldn’t be constantly filled.
The last we heard about storage in U4 was that it was planned for there to generally be less of it. While that’s subject to change, if there’s already less storage space and a weight-based system, then there’s not much reason to add this mechanic.
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Weight-based penalties already do a similar job at combating the hoarding of a lot of items, or at least a lot of large items.
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Less storage space means players aren’t going to be able to hoard as much to begin with. The mechanic only decreases the amount of usable space, and players would be better off just not filling up their entire backpack if it’s going to potentially become unusable space anyways.
If the slots that got damaged weren’t random-ish, then it’s a bit too game-y. Players would either intentionally leave some “fluff” empty space as to just not deal with it when it happens, or if nothing happens to items in the slots when they become unusable then people would just manually put irrelevant stuff in the slots most likely to become unusable.